Assay Detail
Binding
CHEMBL749853
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Compound was tested for inhibition of [125I]eledoisin radioligand binding to NK3 receptor from gerbil cortex
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Gerbillinae |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
SAR of 2-benzyl-4-aminopiperidines: CGP 49823, an orally and centrally active non-peptide NK1 antagonist
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.60 | 6.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL295425 | — | — | 1 | 6.35 |
| CHEMBL290364 | — | — | 1 | 5.58 |
| CHEMBL43912 | — | — | 1 | 5.48 |
| CHEMBL295122 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL295425 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL290364 | — | IC50 | = | 2650.0 | nM | 5.58 |
| CHEMBL43912 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL295122 | — | IC50 | = | 10000.0 | nM | 5.00 |