Assay Detail
Binding
CHEMBL749859
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Antimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M4 subtype
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor M4 (CHEMBL1821) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Muscarinic receptor subtype specificity of (N,N-dialkylamino)alkyl 2-cyclohexyl-2-phenylpropionates: cylexphenes (cyclohexyl-substituted aprophen analogues).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.66 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL286008 | — | — | 1 | 8.82 |
| CHEMBL284137 | — | — | 1 | 8.34 |
| CHEMBL26505 | APROFENE | 2.0 | 1 | 8.13 |
| CHEMBL443780 | — | — | 1 | 7.73 |
| CHEMBL285440 | — | — | 1 | 7.18 |
| CHEMBL24369 | — | — | 1 | 6.76 |
| CHEMBL285898 | — | — | 1 | 6.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL286008 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL284137 | — | Ki | = | 4.6 | nM | 8.34 |
| CHEMBL26505 | APROFENE | Ki | = | 7.4 | nM | 8.13 |
| CHEMBL443780 | — | Ki | = | 18.5 | nM | 7.73 |
| CHEMBL285440 | — | Ki | = | 65.6 | nM | 7.18 |
| CHEMBL24369 | — | Ki | = | 173.0 | nM | 6.76 |
| CHEMBL285898 | — | Ki | = | 209.0 | nM | 6.68 |