Assay Detail
Binding
CHEMBL749862
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Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M4
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Muscarinic acetylcholine receptor M4 (CHEMBL1821) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
6beta-Acetoxynortropane: a potent muscarinic agonist with apparent selectivity toward M2-receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 5.78 | 7.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL64000 | — | — | 1 | 7.48 |
| CHEMBL978 | METHACHOLINE | 4.0 | 1 | 5.80 |
| CHEMBL7303 | ARECOLINE | -1.0 | 1 | 5.62 |
| CHEMBL14 | CARBACHOL | 4.0 | 1 | 5.58 |
| CHEMBL64788 | — | — | 1 | 5.10 |
| CHEMBL294273 | — | — | 1 | 5.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL64000 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL978 | METHACHOLINE | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL7303 | ARECOLINE | Ki | = | 2400.0 | nM | 5.62 |
| CHEMBL14 | CARBACHOL | Ki | = | 2600.0 | nM | 5.58 |
| CHEMBL64788 | — | Ki | = | 7900.0 | nM | 5.10 |
| CHEMBL294273 | — | Ki | = | 8300.0 | nM | 5.08 |