Assay Detail
Binding
CHEMBL749875
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Receptor binding affinity (Ki) against Muscarinic acetylcholine receptor (cerebral cortex) was determined by competition radioligand -[3H]- QNB binding assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Cerebral cortex |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor (CHEMBL2094109) ↗| Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
Publication
3-(2-Benzofuranyl)quinuclidin-2-ene derivatives: novel muscarinic antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 7.05 | 8.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL109405 | — | — | 1 | 8.02 |
| CHEMBL332469 | — | — | 1 | 7.82 |
| CHEMBL113397 | — | — | 1 | 7.70 |
| CHEMBL322144 | — | — | 1 | 7.60 |
| CHEMBL327048 | — | — | 1 | 7.60 |
| CHEMBL109349 | — | — | 1 | 7.41 |
| CHEMBL415510 | — | — | 1 | 7.40 |
| CHEMBL113745 | — | — | 1 | 7.22 |
| CHEMBL109565 | — | — | 1 | 6.94 |
| CHEMBL110690 | — | — | 1 | 6.87 |
| CHEMBL325509 | — | — | 1 | 6.66 |
| CHEMBL109249 | — | — | 1 | 6.54 |
| CHEMBL326431 | — | — | 1 | 6.45 |
| CHEMBL113746 | — | — | 1 | 6.44 |
| CHEMBL432409 | — | — | 1 | 6.19 |
| CHEMBL320745 | — | — | 1 | 5.93 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL109405 | — | Ki | = | 9.6 | nM | 8.02 |
| CHEMBL332469 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL113397 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL322144 | — | Ki | = | 25.3 | nM | 7.60 |
| CHEMBL327048 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL109349 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL415510 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL113745 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL109565 | — | Ki | = | 116.0 | nM | 6.94 |
| CHEMBL110690 | — | Ki | = | 135.0 | nM | 6.87 |
| CHEMBL325509 | — | Ki | = | 221.0 | nM | 6.66 |
| CHEMBL109249 | — | Ki | = | 289.0 | nM | 6.54 |
| CHEMBL326431 | — | Ki | = | 358.0 | nM | 6.45 |
| CHEMBL113746 | — | Ki | = | 364.0 | nM | 6.44 |
| CHEMBL432409 | — | Ki | = | 648.0 | nM | 6.19 |
| CHEMBL320745 | — | Ki | = | 1170.0 | nM | 5.93 |