Assay Detail
Binding
CHEMBL749983
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]-CGS- 19755 binding to rat brain membrane NMDA receptor
12
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Unusual stereochemical preferences of decahydroisoquinoline-3-cargoxylic acid competitive NMDA antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.88 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL65631 | — | — | 6 | 7.60 |
| CHEMBL303126 | — | — | 6 | 6.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL65631 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL65631 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL303126 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL65631 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL65631 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL303126 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL303126 | — | IC50 | = | 3320.0 | nM | 5.48 |
| CHEMBL303126 | — | IC50 | = | 3410.0 | nM | 5.47 |
| CHEMBL303126 | — | IC50 | = | 5160.0 | nM | 5.29 |
| CHEMBL65631 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL65631 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL303126 | — | IC50 | = | 22600.0 | nM | 4.65 |