Assay Detail
Binding
CHEMBL749985
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]TCP from the TCP site of NMDA receptor in rat brain homogenate
7
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Excellent acceleration of the Diels-Alder reaction by microwave irradiation for the synthesis of new fluorine-substituted ligands of NMDA receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.02 | 8.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL317637 | — | — | 1 | 8.44 |
| CHEMBL275528 | PHENCYCLIDINE | 2.0 | 1 | 7.33 |
| CHEMBL317531 | — | — | 2 | 7.33 |
| CHEMBL101120 | — | — | 2 | 7.21 |
| CHEMBL99960 | — | — | 1 | 4.91 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL317637 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL275528 | PHENCYCLIDINE | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL317531 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL101120 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL317531 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL101120 | — | IC50 | = | 141.0 | nM | 6.85 |
| CHEMBL99960 | — | IC50 | = | 12360.0 | nM | 4.91 |