Assay Detail
Functional
CHEMBL749986
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Functional NMDA receptor antagonism expressed as inhibition of NMDA/glycine induced increase in cytosolic calcium in cultured rat cerebellar granule cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Synthesis, biological activity, and absolute stereochemical assignment of NPS 1392: a potent and stereoselective NMDA receptor antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.30 | 8.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL284237 | DIZOCILPINE | 2.0 | 1 | 8.47 |
| CHEMBL294852 | — | — | 1 | 7.20 |
| CHEMBL293092 | — | — | 1 | 7.12 |
| CHEMBL59371 | — | — | 1 | 6.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL284237 | DIZOCILPINE | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL294852 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL293092 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL59371 | — | IC50 | = | 384.0 | nM | 6.42 |