Assay Detail
Binding
CHEMBL749991
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration of compound required to displace [3H]TCP 1-[ 1-(2-thienyl)cyclohexyl]piperidine in whole rat brain homogenate
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Synthesis and biological activity of conformationally constrained 4a-phenanthreneamine derivatives as noncompetitive NMDA antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.48 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL284237 | DIZOCILPINE | 2.0 | 1 | 8.52 |
| CHEMBL151150 | — | — | 1 | 7.83 |
| CHEMBL151238 | — | — | 1 | 7.78 |
| CHEMBL151589 | — | — | 1 | 7.07 |
| CHEMBL149975 | — | — | 1 | 6.86 |
| CHEMBL434324 | — | — | 1 | 6.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL284237 | DIZOCILPINE | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL151150 | — | IC50 | = | 14.7 | nM | 7.83 |
| CHEMBL151238 | — | IC50 | = | 16.8 | nM | 7.78 |
| CHEMBL151589 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL149975 | — | IC50 | = | 137.0 | nM | 6.86 |
| CHEMBL434324 | — | IC50 | = | 151.0 | nM | 6.82 |