Assay Detail
Binding
CHEMBL750000
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Inhibition of [3H]DPDPE binding to guinea pig brain membrane Opioid receptor delta 1 at 1.0 nM
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Electrophilic opioid ligands. Oxygen tethered alpha-methylene-gamma-lactone, acrylate, isothiocyanate, and epoxide derivatives of 6 beta-naltrexol.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 8.03 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL76023 | — | — | 1 | 8.85 |
| CHEMBL350384 | BREMAZOCINE | 2.0 | 1 | 8.82 |
| CHEMBL2310843 | — | — | 1 | 8.21 |
| CHEMBL78932 | — | — | 1 | 8.14 |
| CHEMBL310785 | — | — | 1 | 8.11 |
| CHEMBL78796 | — | — | 1 | 8.04 |
| CHEMBL311912 | — | — | 1 | 7.92 |
| CHEMBL80434 | — | — | 1 | 7.89 |
| CHEMBL19019 | NALTREXONE | 4.0 | 1 | 7.82 |
| CHEMBL80531 | — | — | 1 | 7.72 |
| CHEMBL140278 | — | — | 1 | 7.64 |
| CHEMBL80 | NALOXONE | 4.0 | 1 | 7.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL76023 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL350384 | BREMAZOCINE | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL2310843 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL78932 | — | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL310785 | — | IC50 | = | 7.7 | nM | 8.11 |
| CHEMBL78796 | — | IC50 | = | 9.1 | nM | 8.04 |
| CHEMBL311912 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL80434 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL19019 | NALTREXONE | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL80531 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL140278 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL80 | NALOXONE | IC50 | = | 62.0 | nM | 7.21 |