Assay Detail
Functional
CHEMBL750055
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Stimulation of cation efflux in Nicotinic acetylcholine receptor alpha3-betaX subtype expressing IMR-32 cells
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | IMR-32 |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Expert |
Target
Nicotinic acetylcholine receptor alpha3/betaX (CHEMBL2111384) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Homo sapiens |
Publication
Synthesis and structure-activity relationships of pyridine-modified analogs of 3-[2-((S)-pyrrolidinyl)methoxy]pyridine, A-84543, a potent nicotinic acetylcholine receptor agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 4.89 | 5.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL83473 | — | — | 1 | 5.54 |
| CHEMBL86162 | — | — | 1 | 4.87 |
| CHEMBL84692 | — | — | 1 | 4.74 |
| CHEMBL84149 | — | — | 1 | 4.71 |
| CHEMBL84887 | — | — | 1 | 4.57 |
| CHEMBL86079 | — | — | 1 | - |
| CHEMBL85998 | — | — | 1 | - |
| CHEMBL84827 | — | — | 1 | - |
| CHEMBL312964 | — | — | 1 | - |
| CHEMBL315212 | — | — | 1 | - |
| CHEMBL85956 | — | — | 1 | - |
| CHEMBL312962 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL83473 | — | EC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL86162 | — | EC50 | = | 13400.0 | nM | 4.87 |
| CHEMBL84692 | — | EC50 | = | 18200.0 | nM | 4.74 |
| CHEMBL84149 | — | EC50 | = | 19400.0 | nM | 4.71 |
| CHEMBL84887 | — | EC50 | = | 27100.0 | nM | 4.57 |
| CHEMBL86079 | — | EC50 | > | 1000000.0 | nM | - |
| CHEMBL85998 | — | EC50 | > | 1000000.0 | nM | - |
| CHEMBL84827 | — | EC50 | > | 1000000.0 | nM | - |
| CHEMBL312964 | — | EC50 | > | 1000000.0 | nM | - |
| CHEMBL315212 | — | EC50 | > | 1000000.0 | nM | - |
| CHEMBL85956 | — | EC50 | > | 1000000.0 | nM | - |
| CHEMBL312962 | — | EC50 | > | 1000000.0 | nM | - |