Compound Detail
CHEMBL84887
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Basic Information
| ChEMBL ID | CHEMBL84887 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BFSJLIOTBDRFBB-VIFPVBQESA-N |
3
Targets
3
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
226.7
MW (Da)
2.21
ALogP
3
HBA
0
HBD
25.4
PSA (Ų)
0.74
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 5.85
Ki 1 meas. best 9.19
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Neuronal acetylcholine receptor; alpha4/beta2 CHEMBL1907596 | Ki | 9.19 | 9.19 | 0.6 | 1 |
| Neuronal acetylcholine receptor; alpha4/beta2 CHEMBL1907589 | EC50 | 5.85 | 5.85 | 1400.0 | 1 |
| Nicotinic acetylcholine receptor alpha3/betaX CHEMBL2111384 | EC50 | 4.57 | 4.57 | 27100.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Neuronal acetylcholine receptor; alpha4/beta2 | Ki | = | 0.64 | nM | 9.19 | Binding affinity towards nAChR (alpha4-beta2) by the displacement of [3H](-)-cyt... | 9871663 |
| Neuronal acetylcholine receptor; alpha4/beta2 | EC50 | = | 1400.0 | nM | 5.85 | Stimulation of cation efflux in human nAChR alpha4-beta2 expressing K177 cells | 9871663 |
| Nicotinic acetylcholine receptor alpha3/betaX | EC50 | = | 27100.0 | nM | 4.57 | Stimulation of cation efflux in Nicotinic acetylcholine receptor alpha3-betaX su... | 9871663 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 9871663 | 10.1016/s0960-894x(98)00019-5 | Neuronal acetylcholine receptor; alpha4/beta2 | 4 |
| 9871663 | 10.1016/s0960-894x(98)00019-5 | Nicotinic acetylcholine receptor alpha3/betaX | 1 |
Data from ChEMBL 36 via Core Engine