Assay Detail
Binding
CHEMBL750064
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Binding affinity for NK3 receptor binding sites in guinea pig cortical membranes by using [125I][MePhe7]-NKB as radioligand
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
The rational development of small molecule tachykinin NK3 receptor selective antagonists - the utilisation of a dipeptide chemical library in drug design
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.84 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL444832 | — | — | 1 | 8.05 |
| CHEMBL295301 | — | — | 1 | 7.82 |
| CHEMBL297327 | — | — | 1 | 7.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL444832 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL295301 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL297327 | — | IC50 | = | 22.0 | nM | 7.66 |