Assay Detail
Functional
CHEMBL750065
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Compound was evaluated for concentration-dependent and oscillatory increase in [Ca2+], caused by activation of hNK3 receptors in CHO cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
High affinity, selective neurokinin 2 and neurokinin 3 receptor antagonists from a common structural template.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 7.44 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL437797 | NEUROKININ B | — | 1 | 8.22 |
| CHEMBL106124 | SENKTIDE | — | 1 | 8.15 |
| CHEMBL217406 | NEUROKININ A | — | 1 | 7.28 |
| CHEMBL235363 | SUBSTANCE P | 1.0 | 1 | 6.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL437797 | NEUROKININ B | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL106124 | SENKTIDE | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL217406 | NEUROKININ A | EC50 | = | 53.0 | nM | 7.28 |
| CHEMBL235363 | SUBSTANCE P | EC50 | = | 793.0 | nM | 6.10 |