Assay Detail
Binding
CHEMBL750087
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Binding affinity towards rat alpha2-beta2 neuronal nAChR expressed in Xenopus oocytes using [3H]epibatidine as radioligand
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | Oocyte |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor; alpha2/beta2 (CHEMBL1907592) ↗| Type | PROTEIN COMPLEX |
| Organism | Rattus norvegicus |
Publication
Epibatidine structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 10.66 | 11.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6623 | EPIBATIDINE | — | 1 | 11.00 |
| CHEMBL301901 | — | — | 1 | 10.89 |
| CHEMBL56817 | DESCHLOROEPIBATIDINE | — | 1 | 10.55 |
| CHEMBL56358 | — | — | 1 | 10.21 |
| CHEMBL56682 | — | — | 1 | - |
| CHEMBL54585 | — | — | 1 | - |
| CHEMBL300837 | — | — | 1 | - |
| CHEMBL56677 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6623 | EPIBATIDINE | Ki | = | 0.01 | nM | 11.00 |
| CHEMBL301901 | — | Ki | = | 0.013 | nM | 10.89 |
| CHEMBL56817 | DESCHLOROEPIBATIDINE | Ki | = | 0.028 | nM | 10.55 |
| CHEMBL56358 | — | Ki | = | 0.062 | nM | 10.21 |
| CHEMBL56682 | — | Ki | = | 0.0024 | nM | - |
| CHEMBL54585 | — | Ki | > | 100.0 | nM | - |
| CHEMBL300837 | — | Ki | > | 10.0 | nM | - |
| CHEMBL56677 | — | Ki | > | 100.0 | nM | - |