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Assay Detail

CHEMBL750102

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity towards human neuropeptide Y receptor type 5 using [125I]-PYY as radioligand in baculovirus-infected Sf9 cells
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Cell Type Sf9
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Neuropeptide Y receptor type 5 (CHEMBL4561)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Structure-activity relationship studies on 2-heteroaryl-4-arylimidazoles NPY5 receptor antagonists.
Elliott RL, Oliver RM, LaFlamme JA, Gillaspy ML, Hammond M, Hank RF, Maurer TS, Baker DL, DaSilva-Jardine PA, Stevenson RW, Mack CM, Cassella JV.
Bioorg Med Chem Lett (2003) 13 : 3593 -3596
PubMed 14505677 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 28 7.25 8.80

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL326483 1 8.80
CHEMBL122527 1 8.46
CHEMBL120760 1 8.40
CHEMBL120586 1 8.31
CHEMBL325727 1 8.10
CHEMBL339652 1 7.85
CHEMBL333310 1 7.80
CHEMBL119507 1 7.72
CHEMBL120332 1 7.68
CHEMBL120117 1 7.57
CHEMBL120377 1 7.52
CHEMBL120431 1 7.47
CHEMBL327027 1 7.47
CHEMBL325704 1 7.43
CHEMBL332561 1 7.40
CHEMBL332582 1 7.40
CHEMBL422608 1 7.25
CHEMBL333509 1 7.16
CHEMBL332598 1 6.94
CHEMBL122120 1 6.83
CHEMBL323658 1 6.68
CHEMBL332381 1 6.64
CHEMBL120336 1 6.28
CHEMBL325171 1 5.84
CHEMBL326736 1 5.82
CHEMBL120538 1 5.52
CHEMBL116488 1 5.32
CHEMBL420541 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL326483 Ki = 1.6 nM 8.80
CHEMBL122527 Ki = 3.5 nM 8.46
CHEMBL120760 Ki = 4.0 nM 8.40
CHEMBL120586 Ki = 4.9 nM 8.31
CHEMBL325727 Ki = 8.0 nM 8.10
CHEMBL339652 Ki = 14.0 nM 7.85
CHEMBL333310 Ki = 16.0 nM 7.80
CHEMBL119507 Ki = 19.0 nM 7.72
CHEMBL120332 Ki = 21.0 nM 7.68
CHEMBL120117 Ki = 27.0 nM 7.57
CHEMBL120377 Ki = 30.0 nM 7.52
CHEMBL120431 Ki = 34.0 nM 7.47
CHEMBL327027 Ki = 34.0 nM 7.47
CHEMBL325704 Ki = 37.0 nM 7.43
CHEMBL332561 Ki = 40.0 nM 7.40
CHEMBL332582 Ki = 40.0 nM 7.40
CHEMBL422608 Ki = 56.0 nM 7.25
CHEMBL333509 Ki = 69.0 nM 7.16
CHEMBL332598 Ki = 116.0 nM 6.94
CHEMBL122120 Ki = 148.0 nM 6.83
CHEMBL323658 Ki = 210.0 nM 6.68
CHEMBL332381 Ki = 231.0 nM 6.64
CHEMBL120336 Ki = 525.0 nM 6.28
CHEMBL325171 Ki = 1449.0 nM 5.84
CHEMBL326736 Ki = 1527.0 nM 5.82
CHEMBL120538 Ki = 3001.0 nM 5.52
CHEMBL116488 Ki = 4769.0 nM 5.32
CHEMBL420541 Ki > 10000.0 nM -