Assay Detail
Binding
CHEMBL750149
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against N-methyl-D-aspartate glutamate receptor using [3H]CPP as radioligand
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
N-methyl-D-aspartic acid receptor agonists: resolution, absolute stereochemistry, and pharmacology of the enantiomers of 2-amino-2-(3-hydroxy-5-methyl-4-isoxazolyl)acetic acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.86 | 5.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL299243 | — | — | 1 | 5.43 |
| CHEMBL280585 | — | — | 1 | 5.35 |
| CHEMBL291278 | N-METHYL-D-ASPARTIC ACID (NMDA) | 2.0 | 1 | 4.46 |
| CHEMBL292685 | — | — | 1 | 4.21 |
| CHEMBL284895 | — | — | 1 | - |
| CHEMBL276815 | (S)-AMPA | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL299243 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL280585 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL291278 | N-METHYL-D-ASPARTIC ACID (NMDA) | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL292685 | — | IC50 | = | 61000.0 | nM | 4.21 |
| CHEMBL284895 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL276815 | (S)-AMPA | IC50 | > | 100000.0 | nM | - |