Assay Detail
Binding
CHEMBL750152
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity evaluated by its ability to displace [3H]CPP from N-methyl-D-aspartate glutamate receptor in rat cortical membranes at 10E-5 concentration of the compound
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Exploration of N-phosphonoalkyl-, N-phosphonoalkenyl-, and N-(phosphonoalkyl)phenyl-spaced alpha-amino acids as competitive N-methyl-D-aspartic acid antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.70 | 6.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL28862 | — | — | 1 | 6.54 |
| CHEMBL274440 | AP-7 | — | 1 | 6.11 |
| CHEMBL443231 | — | — | 1 | 5.40 |
| CHEMBL284880 | — | — | 1 | 4.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL28862 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL274440 | AP-7 | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL443231 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL284880 | — | IC50 | = | 18000.0 | nM | 4.75 |