Assay Detail
Binding
CHEMBL750165
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Tested to inhibit the conversion of [3H]L-arginine to [3H]L-citrulline catalyzed by inducible NOS from human DLD-1 cells.
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | DLD-1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
1,2-diaminobenzimidazoles : Selective inhibitors of nitric oxide synthase derived from aminoguanidine
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.50 | 4.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL247378 | 7-NITROINDAZOLE | — | 1 | 4.62 |
| CHEMBL41060 | — | — | 1 | 4.60 |
| CHEMBL225304 | PIMAGEDINE | 2.0 | 1 | 4.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL247378 | 7-NITROINDAZOLE | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL41060 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL225304 | PIMAGEDINE | IC50 | = | 54000.0 | nM | 4.27 |