Assay Detail
Binding
CHEMBL750226
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Binding affinity was determined against human NK2 receptor in CHO cells using [125I]neurokinin A as radioligand
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
A Non-peptidic photoactivatable antagonist for mapping the antagonist binding site of the tachykinin NK2 receptor
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.64 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL308148 | SAREDUTANT | 3.0 | 1 | 9.10 |
| CHEMBL348599 | — | — | 1 | 8.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL308148 | SAREDUTANT | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL348599 | — | IC50 | = | 6.7 | nM | 8.17 |