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Assay Detail

CHEMBL750244

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human neuronal nitric oxide synthase
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

Nitric oxide synthase 1 (CHEMBL3568)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Fluorinated dihydroquinolines as potent n-NOS inhibitors.
Jaroch S, Rehwinkel H, Hölscher P, Sülzle D, Burton G, Hillmann M, McDonald FM, Miklautz H.
Bioorg Med Chem Lett (2004) 14 : 743 -746
PubMed 14741281 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 6.62 7.38

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL162416 1 7.38
CHEMBL349071 1 7.00
CHEMBL292099 1 6.85
CHEMBL61969 1 6.80
CHEMBL314943 1 6.77
CHEMBL314186 1 6.54
CHEMBL162455 1 6.54
CHEMBL161925 1 6.51
CHEMBL162365 1 6.41
CHEMBL350281 1 6.23
CHEMBL354230 1 6.18
CHEMBL86961 1 6.17

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL162416 IC50 = 42.0 nM 7.38
CHEMBL349071 IC50 = 100.0 nM 7.00
CHEMBL292099 IC50 = 140.0 nM 6.85
CHEMBL61969 IC50 = 160.0 nM 6.80
CHEMBL314943 IC50 = 170.0 nM 6.77
CHEMBL314186 IC50 = 290.0 nM 6.54
CHEMBL162455 IC50 = 290.0 nM 6.54
CHEMBL161925 IC50 = 310.0 nM 6.51
CHEMBL162365 IC50 = 390.0 nM 6.41
CHEMBL350281 IC50 = 590.0 nM 6.23
CHEMBL354230 IC50 = 660.0 nM 6.18
CHEMBL86961 IC50 = 680.0 nM 6.17