Assay Detail
Binding
CHEMBL750255
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Inhibitory potency of compound in presence of Mn2+ ion against NS5B HCV polymerase
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepacivirus hominis |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
RNA-directed RNA polymerase (CHEMBL4296320) ↗| Type | SINGLE PROTEIN |
| Organism | Hepacivirus hominis |
Publication
The monoethyl ester of meconic acid is an active site inhibitor of HCV NS5B RNA-dependent RNA polymerase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.43 | 6.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL109569 | — | — | 1 | 6.19 |
| CHEMBL323046 | — | — | 1 | 6.10 |
| CHEMBL110021 | — | — | 1 | 5.40 |
| CHEMBL109516 | — | — | 1 | 4.75 |
| CHEMBL326470 | — | — | 1 | 4.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL109569 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL323046 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL110021 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL109516 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL326470 | — | IC50 | = | 19000.0 | nM | 4.72 |