Compound Detail
CHEMBL326470
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL326470 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | IUKHRRJJZYWSMG-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
206.2
MW (Da)
1.20
ALogP
4
HBA
2
HBD
87.7
PSA (Ų)
0.73
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 4.72
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| RNA-directed RNA polymerase CHEMBL4296320 | IC50 | 4.72 | 4.68 | 19000.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| RNA-directed RNA polymerase | IC50 | = | 19000.0 | nM | 4.72 | Inhibitory potency of compound in presence of Mn2+ ion against NS5B HCV polymera... | 15149686 |
| RNA-directed RNA polymerase | IC50 | = | 23000.0 | nM | 4.64 | Inhibitory potency of compound in presence of Mg2+ ion against NS5B HCV polymera... | 15149686 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15149686 | 10.1016/j.bmcl.2004.03.087 | RNA-directed RNA polymerase | 2 |
| 15149686 | 10.1016/j.bmcl.2004.03.087 | Hepatitis C virus | 1 |
Data from ChEMBL 36 via Core Engine