Assay Detail
Functional
CHEMBL750321
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound ability to inhibit anchorage-independent growth of NIH-H tumor cell lines in soft agar.
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NIH-H |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
(+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H-benzo[5, 6]cyclohepta[1,2-b]- pyridin-11(R)-yl)-1-piperidinyl]-2-oxo-ethyl]-1-piperidinecarboxamid e (SCH-66336): a very potent farnesyl protein transferase inhibitor as a novel antitumor agent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.67 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL333864 | — | — | 1 | 7.30 |
| CHEMBL298734 | LONAFARNIB | 4.0 | 1 | 7.14 |
| CHEMBL358957 | — | — | 1 | 6.70 |
| CHEMBL342099 | — | — | 1 | 6.60 |
| CHEMBL358796 | — | — | 1 | 6.54 |
| CHEMBL69954 | — | — | 1 | 6.30 |
| CHEMBL344068 | — | — | 1 | 6.12 |
| CHEMBL357148 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL333864 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL298734 | LONAFARNIB | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL358957 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL342099 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL358796 | — | IC50 | = | 286.0 | nM | 6.54 |
| CHEMBL69954 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL344068 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL357148 | — | IC50 | < | 50.0 | nM | - |