Assay Detail
Binding
CHEMBL750360
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated for potency towards nicotinic acetylcholine receptor in rat P2 brain membranes using [3H]nicotine as a radioligand
5
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor (CHEMBL2094110) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Synthesis of UB-165: A novel nicotinic ligand and anatoxin-a/epibatidine hybrid
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 9.46 | 10.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6623 | EPIBATIDINE | — | 1 | 10.68 |
| CHEMBL1086655 | — | — | 1 | 9.77 |
| CHEMBL63102 | — | — | 2 | 9.57 |
| CHEMBL25619 | — | — | 1 | 8.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6623 | EPIBATIDINE | Ki | = | 0.021 | nM | 10.68 |
| CHEMBL1086655 | — | Ki | = | 0.17 | nM | 9.77 |
| CHEMBL63102 | — | Ki | = | 0.27 | nM | 9.57 |
| CHEMBL25619 | — | Ki | = | 1.25 | nM | 8.90 |
| CHEMBL63102 | — | Ki | = | 4.4 | nM | 8.36 |