Assay Detail
Binding
CHEMBL750361
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Binding affinity towards nicotinic acetylcholine receptor using [3H]nicotine as radioligand in rat brain homogenates
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor (CHEMBL2094110) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
A comparison of the binding of three series of nicotinic ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 28 | 7.57 | 10.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL59986 | — | — | 1 | 10.30 |
| CHEMBL293435 | — | — | 1 | 9.35 |
| CHEMBL58231 | — | — | 1 | 9.35 |
| CHEMBL61013 | — | — | 1 | 9.20 |
| CHEMBL62128 | — | — | 1 | 8.99 |
| CHEMBL3 | NICOTINE | 4.0 | 1 | 8.89 |
| CHEMBL294757 | — | — | 1 | 8.74 |
| CHEMBL61772 | — | — | 1 | 8.16 |
| CHEMBL61883 | — | — | 1 | 7.95 |
| CHEMBL303530 | — | — | 1 | 7.85 |
| CHEMBL62015 | — | — | 1 | 7.80 |
| CHEMBL61616 | — | — | 1 | 7.68 |
| CHEMBL57912 | — | — | 1 | 7.66 |
| CHEMBL292114 | — | — | 1 | 7.66 |
| CHEMBL60792 | — | — | 1 | 7.55 |
| CHEMBL60141 | — | — | 1 | 7.39 |
| CHEMBL292655 | — | — | 1 | 7.21 |
| CHEMBL60124 | — | — | 1 | 7.18 |
| CHEMBL59967 | — | — | 1 | 7.03 |
| CHEMBL61520 | — | — | 1 | 7.03 |
| CHEMBL61527 | — | — | 1 | 6.94 |
| CHEMBL60937 | — | — | 1 | 6.54 |
| CHEMBL58616 | — | — | 1 | 6.35 |
| CHEMBL61165 | — | — | 1 | 6.19 |
| CHEMBL294499 | — | — | 1 | 6.07 |
| CHEMBL59420 | — | — | 1 | 5.96 |
| CHEMBL61764 | — | — | 1 | 5.61 |
| CHEMBL60356 | — | — | 1 | 5.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL59986 | — | Ki | = | 0.05 | nM | 10.30 |
| CHEMBL293435 | — | Ki | = | 0.45 | nM | 9.35 |
| CHEMBL58231 | — | Ki | = | 0.45 | nM | 9.35 |
| CHEMBL61013 | — | Ki | = | 0.63 | nM | 9.20 |
| CHEMBL62128 | — | Ki | = | 1.03 | nM | 8.99 |
| CHEMBL3 | NICOTINE | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL294757 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL61772 | — | Ki | = | 6.9 | nM | 8.16 |
| CHEMBL61883 | — | Ki | = | 11.2 | nM | 7.95 |
| CHEMBL303530 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL62015 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL61616 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL57912 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL292114 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL60792 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL60141 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL292655 | — | Ki | = | 62.0 | nM | 7.21 |
| CHEMBL60124 | — | Ki | = | 66.0 | nM | 7.18 |
| CHEMBL59967 | — | Ki | = | 93.0 | nM | 7.03 |
| CHEMBL61520 | — | Ki | = | 93.0 | nM | 7.03 |
| CHEMBL61527 | — | Ki | = | 115.0 | nM | 6.94 |
| CHEMBL60937 | — | Ki | = | 290.0 | nM | 6.54 |
| CHEMBL58616 | — | Ki | = | 447.0 | nM | 6.35 |
| CHEMBL61165 | — | Ki | = | 640.0 | nM | 6.19 |
| CHEMBL294499 | — | Ki | = | 850.0 | nM | 6.07 |
| CHEMBL59420 | — | Ki | = | 1110.0 | nM | 5.96 |
| CHEMBL61764 | — | Ki | = | 2470.0 | nM | 5.61 |
| CHEMBL60356 | — | Ki | = | 4070.0 | nM | 5.39 |