Assay Detail
Functional
CHEMBL750386
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Inhibitory concentration required for 50 percent inhibition of opioid receptor delta 1 induced contractions in mouse vas deferens (MVD) smooth muscle contraction assays
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Identification of opioid ligands possessing mixed micro agonist/delta antagonist activity among pyridomorphinans derived from naloxone, oxymorphone, and hydromorphone [correction of hydropmorphone].
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.89 | 8.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL31421 | — | — | 1 | 8.24 |
| CHEMBL611432 | — | — | 1 | 7.32 |
| CHEMBL611687 | — | — | 1 | 6.82 |
| CHEMBL611434 | — | — | 1 | 6.67 |
| CHEMBL283287 | — | — | 1 | 6.61 |
| CHEMBL611437 | — | — | 1 | 6.31 |
| CHEMBL611688 | — | — | 1 | 6.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL31421 | — | IC50 | = | 5.81 | nM | 8.24 |
| CHEMBL611432 | — | IC50 | = | 48.4 | nM | 7.32 |
| CHEMBL611687 | — | IC50 | = | 152.0 | nM | 6.82 |
| CHEMBL611434 | — | IC50 | = | 213.0 | nM | 6.67 |
| CHEMBL283287 | — | IC50 | = | 243.0 | nM | 6.61 |
| CHEMBL611437 | — | IC50 | = | 489.0 | nM | 6.31 |
| CHEMBL611688 | — | IC50 | = | 565.0 | nM | 6.25 |