Assay Detail
Binding
CHEMBL750388
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Inhibitory potency against delta Opioid receptor delta 1 in longitudinal muscle preparation of mouse vas deferens
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Evidence of the preferential involvement of mu receptors in analgesia using enkephalins highly selective for peripheral mu or delta receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.73 | 9.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL340032 | DADLE | — | 1 | 9.27 |
| CHEMBL14230 | — | — | 1 | 9.24 |
| CHEMBL14036 | — | — | 1 | 8.96 |
| CHEMBL14204 | — | — | 1 | 8.21 |
| CHEMBL13786 | — | — | 1 | 7.89 |
| CHEMBL274204 | — | — | 1 | 7.80 |
| CHEMBL13894 | — | — | 1 | 7.64 |
| CHEMBL70 | MORPHINE | 4.0 | 1 | 6.41 |
| CHEMBL280274 | — | — | 1 | 5.96 |
| CHEMBL14094 | — | — | 1 | 5.91 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL340032 | DADLE | IC50 | = | 0.54 | nM | 9.27 |
| CHEMBL14230 | — | IC50 | = | 0.58 | nM | 9.24 |
| CHEMBL14036 | — | IC50 | = | 1.09 | nM | 8.96 |
| CHEMBL14204 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL13786 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL274204 | — | IC50 | = | 15.7 | nM | 7.80 |
| CHEMBL13894 | — | IC50 | = | 23.1 | nM | 7.64 |
| CHEMBL70 | MORPHINE | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL280274 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL14094 | — | IC50 | = | 1220.0 | nM | 5.91 |