Assay Detail
Functional
CHEMBL750394
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Tested for agonist activity against delta opioid receptor mouse vas deferens
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Tissue | Vas deferens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Probes for narcotic receptor mediated phenomena. 19. Synthesis of (+)-4-[(alpha R)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3- methoxybenzyl]-N,N-diethylbenzamide (SNC 80): a highly selective, nonpeptide delta opioid receptor agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 8.13 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL303855 | — | — | 1 | 9.70 |
| CHEMBL26575 | DELTORPHIN | — | 1 | 9.07 |
| CHEMBL611159 | — | — | 1 | 8.56 |
| CHEMBL31421 | — | — | 1 | 8.29 |
| CHEMBL428142 | — | — | 1 | 8.27 |
| CHEMBL67378 | — | — | 1 | 7.51 |
| CHEMBL2052013 | — | — | 1 | 5.49 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL303855 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL26575 | DELTORPHIN | IC50 | = | 0.85 | nM | 9.07 |
| CHEMBL611159 | — | IC50 | = | 2.73 | nM | 8.56 |
| CHEMBL31421 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL428142 | — | IC50 | = | 5.34 | nM | 8.27 |
| CHEMBL67378 | — | IC50 | = | 30.9 | nM | 7.51 |
| CHEMBL2052013 | — | IC50 | = | 3250.0 | nM | 5.49 |