Assay Detail
Binding
CHEMBL750412
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity against delta-opiate receptor (human) using [3H]-DPDPE radioligand
46
Total Activities
46
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
From hit to lead. Combining two complementary methods for focused library design. Application to mu opiate ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 46 | 6.36 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2368861 | BUPRENORPHINE HYDROCHLORIDE | 4.0 | 1 | 9.05 |
| CHEMBL115222 | — | — | 1 | 7.94 |
| CHEMBL114379 | — | — | 1 | 7.43 |
| CHEMBL420863 | — | — | 1 | 6.93 |
| CHEMBL1707 | LOPERAMIDE HYDROCHLORIDE | 4.0 | 1 | 6.91 |
| CHEMBL115652 | — | — | 1 | 6.86 |
| CHEMBL80 | NALOXONE | 4.0 | 1 | 6.82 |
| CHEMBL2096625 | — | — | 1 | 6.62 |
| CHEMBL324297 | — | — | 1 | 6.58 |
| CHEMBL895 | NALBUPHINE | 4.0 | 1 | 6.45 |
| CHEMBL596 | FENTANYL | 4.0 | 1 | 6.37 |
| CHEMBL325842 | — | — | 1 | 6.21 |
| CHEMBL115229 | — | — | 1 | 5.98 |
| CHEMBL651 | METHADONE | 4.0 | 1 | 5.96 |
| CHEMBL326962 | — | — | 1 | 5.92 |
| CHEMBL112191 | — | — | 1 | 5.85 |
| CHEMBL114825 | — | — | 1 | 5.75 |
| CHEMBL115280 | — | — | 1 | 5.74 |
| CHEMBL115444 | — | — | 1 | 5.60 |
| CHEMBL114280 | — | — | 1 | 5.48 |
| CHEMBL325750 | — | — | 1 | 5.38 |
| CHEMBL326320 | — | — | 1 | 5.25 |
| CHEMBL419214 | — | — | 1 | 5.15 |
| CHEMBL324142 | — | — | 1 | - |
| CHEMBL332697 | — | — | 1 | - |
| CHEMBL324170 | — | — | 1 | - |
| CHEMBL324257 | — | — | 1 | - |
| CHEMBL326538 | — | — | 1 | - |
| CHEMBL325874 | — | — | 1 | - |
| CHEMBL115076 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2368861 | BUPRENORPHINE HYDROCHLORIDE | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL115222 | — | IC50 | = | 11.4 | nM | 7.94 |
| CHEMBL114379 | — | IC50 | = | 37.4 | nM | 7.43 |
| CHEMBL420863 | — | IC50 | = | 117.0 | nM | 6.93 |
| CHEMBL1707 | LOPERAMIDE HYDROCHLORIDE | IC50 | = | 123.0 | nM | 6.91 |
| CHEMBL115652 | — | IC50 | = | 138.0 | nM | 6.86 |
| CHEMBL80 | NALOXONE | IC50 | = | 151.0 | nM | 6.82 |
| CHEMBL2096625 | — | IC50 | = | 242.0 | nM | 6.62 |
| CHEMBL324297 | — | IC50 | = | 264.0 | nM | 6.58 |
| CHEMBL895 | NALBUPHINE | IC50 | = | 353.0 | nM | 6.45 |
| CHEMBL596 | FENTANYL | IC50 | = | 431.0 | nM | 6.37 |
| CHEMBL325842 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL115229 | — | IC50 | = | 1040.0 | nM | 5.98 |
| CHEMBL651 | METHADONE | IC50 | = | 1090.0 | nM | 5.96 |
| CHEMBL326962 | — | IC50 | = | 1190.0 | nM | 5.92 |
| CHEMBL112191 | — | IC50 | = | 1410.0 | nM | 5.85 |
| CHEMBL114825 | — | IC50 | = | 1765.0 | nM | 5.75 |
| CHEMBL115280 | — | IC50 | = | 1840.0 | nM | 5.74 |
| CHEMBL115444 | — | IC50 | = | 2530.0 | nM | 5.60 |
| CHEMBL114280 | — | IC50 | = | 3330.0 | nM | 5.48 |
| CHEMBL325750 | — | IC50 | = | 4120.0 | nM | 5.38 |
| CHEMBL326320 | — | IC50 | = | 5640.0 | nM | 5.25 |
| CHEMBL419214 | — | IC50 | = | 7130.0 | nM | 5.15 |
| CHEMBL115284 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL325697 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL114204 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL114824 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL114940 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL111918 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL325674 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL324479 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL607 | MEPERIDINE | IC50 | > | 10000.0 | nM | - |
| CHEMBL333843 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL114327 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL115549 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL324471 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL420500 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL113811 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL369475 | CODEINE MONOHYDRATE | IC50 | > | 10000.0 | nM | - |
| CHEMBL115076 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL325874 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL326538 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL324257 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL324170 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL332697 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL324142 | — | IC50 | > | 10000.0 | nM | - |