Assay Detail
Binding
CHEMBL750448
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In vitro Binding affinity towards alpha-7 nAChR was determined
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor subunit alpha-7 (CHEMBL3365) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
The 5-HT3 antagonist tropisetron (ICS 205-930) is a potent and selective alpha7 nicotinic receptor partial agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.87 | 8.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL108799 | — | — | 1 | 8.64 |
| CHEMBL111583 | — | — | 1 | 8.19 |
| CHEMBL56564 | TROPISETRON | 3.0 | 1 | 8.16 |
| CHEMBL320963 | — | — | 1 | 8.06 |
| CHEMBL3 | NICOTINE | 4.0 | 1 | 6.32 |
| CHEMBL46 | ONDANSETRON | 4.0 | 1 | - |
| CHEMBL289469 | GRANISETRON | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL108799 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL111583 | — | Ki | = | 6.4 | nM | 8.19 |
| CHEMBL56564 | TROPISETRON | Ki | = | 6.9 | nM | 8.16 |
| CHEMBL320963 | — | Ki | = | 8.8 | nM | 8.06 |
| CHEMBL3 | NICOTINE | Ki | = | 480.0 | nM | 6.32 |
| CHEMBL46 | ONDANSETRON | Ki | > | 3000.0 | nM | - |
| CHEMBL289469 | GRANISETRON | Ki | > | 10000.0 | nM | - |