Neuronal acetylcholine receptor subunit alpha-7 · SINGLE PROTEIN · Mus musculus
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As of 2026-09-13Protein identity stays anchored to UniProt P49582. Use UniProt P49582 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P49582 as the stable identity anchor, then attach disease evidence before program review.
Neuronal acetylcholine receptor subunit alpha-7
Review this target as Neuronal acetylcholine receptor subunit alpha-7, mapped to UniProt P49582. Sequence length is 502 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Neuronal acetylcholine receptor subunit alpha-7 as ChEMBL target CHEMBL3365, mapped to UniProt P49582. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Neuronal acetylcholine receptor subunit alpha-7 |
| Target Type | SINGLE PROTEIN |
| Organism | Mus musculus |
| UniProt | P49582 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Neuronal acetylcholine receptor subunit alpha-7 |
| UniProt Accession | P49582 |
| Component Type | Protein |
| Sequence Length | 502 aa |
Neuronal acetylcholine receptor subunit alpha-7
Review this target as Neuronal acetylcholine receptor subunit alpha-7, mapped to UniProt P49582. Sequence length is 502 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL108799 | 8.64 | Ki | 2.3 | Preclinical |
| CHEMBL111583 | 8.19 | Ki | 6.4 | Preclinical |
| CHEMBL56564 | 8.16 | Ki | 6.9 | Clinical |
| CHEMBL2151573 | 8.15 | Ki | 7.04 | Preclinical |
| CHEMBL320963 | 8.06 | Ki | 8.8 | Preclinical |
| CHEMBL3217150 | 7.16 | Ki | 69.0 | Preclinical |
| CHEMBL3 | 6.61 | Ki | 244.0 | Approved |
| CHEMBL1783881 | 6.35 | Ki | 449.0 | Preclinical |
| CHEMBL1782074 | 6.13 | Ki | 733.0 | Preclinical |
| CHEMBL1783886 | 5.96 | Ki | 1100.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell membrane format | 2 | 2 | 7.4 |
| cell-based format | 2 | 0 | — |
| single protein format | 1 | 5 | 7.9 |
| tissue-based format | 1 | 9 | 5.8 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 0 | — |