Assay Detail
Functional
CHEMBL750462
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effect on synaptosomal uptake inhibition of Noradrenaline (NA)
12
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Neuroleptic activity and dopamine-uptake inhibition in 1-piperazino-3-phenylindans.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.96 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2096748 | — | — | 1 | 9.52 |
| CHEMBL2447974 | — | — | 6 | 8.60 |
| CHEMBL322067 | — | — | 1 | 8.27 |
| CHEMBL273575 | NOMIFENSINE | 4.0 | 1 | 8.18 |
| CHEMBL176506 | — | — | 1 | 8.17 |
| CHEMBL2448057 | — | — | 2 | 8.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2096748 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL2447974 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL322067 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL273575 | NOMIFENSINE | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL176506 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL2447974 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL2447974 | — | IC50 | = | 7.7 | nM | 8.11 |
| CHEMBL2448057 | — | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL2448057 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2447974 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL2447974 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL2447974 | — | IC50 | = | 910.0 | nM | 6.04 |