Assay Detail
Binding
CHEMBL750507
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding activity against N-methyl-D-aspartate glutamate receptor in rat brain homogenate using [3H]-glycine as the radioligand.
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
4-[(Carboxymethyl)oxy]- and 4-[(carboxymethyl)amino]-5,7-dichloroquinoline-2-carboxylic acid: new antagonists of the strychnine-insensitive glycine binding site on the N-methyl-D-aspartate receptor complex.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.07 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL50267 | — | — | 1 | 7.10 |
| CHEMBL105396 | — | — | 1 | 7.00 |
| CHEMBL311389 | 7-CHLOROKYNURENIC ACID | -1.0 | 1 | 6.40 |
| CHEMBL322777 | — | — | 1 | 5.05 |
| CHEMBL299155 | TRANSTORINE | 1.0 | 1 | 4.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL50267 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL105396 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL311389 | 7-CHLOROKYNURENIC ACID | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL322777 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL299155 | TRANSTORINE | IC50 | = | 16000.0 | nM | 4.80 |