Assay Detail
Binding
CHEMBL750508
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Affinity of [3H]-CGS- 19755 radioligand to rat N-methyl-D-aspartate (NMDA) receptor
30
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Structure-activity studies of 6-substituted decahydroisoquinoline-3-carboxylic acid AMPA receptor antagonists. 2. Effects of distal acid bioisosteric substitution, absolute stereochemical preferences, and in vivo activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 4.39 | 4.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL14935 | TEZAMPANEL ANHYDROUS | 2.0 | 2 | 4.92 |
| CHEMBL309342 | — | — | 2 | 4.74 |
| CHEMBL70773 | — | — | 2 | 4.53 |
| CHEMBL72573 | — | — | 1 | 4.36 |
| CHEMBL71755 | — | — | 3 | 4.22 |
| CHEMBL71167 | — | — | 1 | 4.21 |
| CHEMBL73837 | — | — | 1 | 4.21 |
| CHEMBL73356 | — | — | 1 | - |
| CHEMBL311632 | — | — | 1 | - |
| CHEMBL71043 | — | — | 1 | - |
| CHEMBL423498 | — | — | 2 | - |
| CHEMBL307281 | — | — | 1 | - |
| CHEMBL72413 | — | — | 1 | - |
| CHEMBL73072 | — | — | 1 | - |
| CHEMBL440493 | — | — | 1 | - |
| CHEMBL70937 | — | — | 1 | - |
| CHEMBL422589 | — | — | 1 | - |
| CHEMBL72592 | — | — | 1 | - |
| CHEMBL433294 | — | — | 1 | - |
| CHEMBL70535 | — | — | 1 | - |
| CHEMBL72544 | — | — | 1 | - |
| CHEMBL306851 | — | — | 1 | - |
| CHEMBL307562 | — | — | 1 | - |
| CHEMBL304282 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL14935 | TEZAMPANEL ANHYDROUS | IC50 | = | 12100.0 | nM | 4.92 |
| CHEMBL309342 | — | IC50 | = | 18100.0 | nM | 4.74 |
| CHEMBL14935 | TEZAMPANEL ANHYDROUS | IC50 | = | 26400.0 | nM | 4.58 |
| CHEMBL70773 | — | IC50 | = | 29800.0 | nM | 4.53 |
| CHEMBL309342 | — | IC50 | = | 29400.0 | nM | 4.53 |
| CHEMBL72573 | — | IC50 | = | 43900.0 | nM | 4.36 |
| CHEMBL70773 | — | IC50 | = | 47900.0 | nM | 4.32 |
| CHEMBL71755 | — | IC50 | = | 60600.0 | nM | 4.22 |
| CHEMBL71167 | — | IC50 | = | 60900.0 | nM | 4.21 |
| CHEMBL73837 | — | IC50 | = | 61800.0 | nM | 4.21 |
| CHEMBL71755 | — | IC50 | = | 76900.0 | nM | 4.11 |
| CHEMBL71755 | — | IC50 | = | 99200.0 | nM | 4.00 |
| CHEMBL71043 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL440493 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL73356 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL72413 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL423498 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL304282 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL70937 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL311632 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL72592 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL307281 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL433294 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL73072 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL70535 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL72544 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL306851 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL307562 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL423498 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL422589 | — | IC50 | > | 100000.0 | nM | - |