Assay Detail
Binding
CHEMBL750540
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Inhibition of Neutral endopeptidase
12
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
N-formyl hydroxylamine containing dipeptides: generation of a new class of vasopeptidase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.49 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL90388 | — | — | 1 | 8.89 |
| CHEMBL89760 | — | — | 2 | 8.77 |
| CHEMBL177551 | — | — | 1 | 8.74 |
| CHEMBL89563 | — | — | 1 | 8.52 |
| CHEMBL289556 | OMAPATRILAT | 2.0 | 1 | 8.05 |
| CHEMBL89533 | — | — | 1 | 7.75 |
| CHEMBL42583 | SAMPATRILAT | 2.0 | 1 | 7.70 |
| CHEMBL314626 | — | — | 1 | 5.90 |
| CHEMBL2370089 | — | — | 1 | 4.03 |
| CHEMBL315395 | — | — | 1 | - |
| CHEMBL88228 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL90388 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL89760 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL177551 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL89563 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL289556 | OMAPATRILAT | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL89533 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL42583 | SAMPATRILAT | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL89760 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL314626 | — | IC50 | = | 1270.0 | nM | 5.90 |
| CHEMBL2370089 | — | IC50 | = | 93000.0 | nM | 4.03 |
| CHEMBL315395 | — | IC50 | = | 705000.0 | nM | - |
| CHEMBL88228 | — | IC50 | = | 214000.0 | nM | - |