Assay Detail
Binding
CHEMBL750583
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Tested for binding activity against kappa opioid receptor using [3H]U-69593 ligand
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis of naltrexone-derived delta-opioid antagonists. Role of conformation of the delta address moiety.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.96 | 8.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL610550 | — | — | 1 | 8.66 |
| CHEMBL610292 | — | — | 1 | 8.66 |
| CHEMBL252172 | BNTX | — | 1 | 8.23 |
| CHEMBL610293 | — | — | 1 | 7.90 |
| CHEMBL567175 | NALTRINDOLE | — | 1 | 7.85 |
| CHEMBL610046 | — | — | 1 | 7.60 |
| CHEMBL610290 | — | — | 1 | 7.60 |
| CHEMBL101519 | — | — | 1 | 7.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL610550 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL610292 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL252172 | BNTX | Ki | = | 5.9 | nM | 8.23 |
| CHEMBL610293 | — | Ki | = | 12.5 | nM | 7.90 |
| CHEMBL567175 | NALTRINDOLE | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL610046 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL610290 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL101519 | — | Ki | = | 66.0 | nM | 7.18 |