Assay Detail
Binding
CHEMBL750628
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Tested in vitro for its ability to displace 3[H] clozapine from non-muscarinic receptor in rat brain
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Affinity of 10-(4-methylpiperazino)dibenz[b,f]oxepins for clozapine and spiroperidol binding sites in rat brain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 8.02 | 8.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7821 | — | — | 1 | 8.43 |
| CHEMBL89970 | — | — | 1 | 8.40 |
| CHEMBL90882 | — | — | 1 | 8.14 |
| CHEMBL88464 | — | — | 1 | 8.03 |
| CHEMBL7617 | — | — | 1 | 8.00 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 7.89 |
| CHEMBL275696 | — | — | 1 | 7.89 |
| CHEMBL415300 | ISOCLOZAPINE | — | 1 | 7.77 |
| CHEMBL73538 | — | — | 1 | 7.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7821 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL89970 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL90882 | — | IC50 | = | 7.3 | nM | 8.14 |
| CHEMBL88464 | — | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL7617 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL42 | CLOZAPINE | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL275696 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL415300 | ISOCLOZAPINE | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL73538 | — | IC50 | = | 25.0 | nM | 7.60 |