Assay Detail
Binding
CHEMBL750652
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In vitro inhibition of human neuronal nitric oxide synthase
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Structure-activity relationships of potent, selective inhibitors of neuronal nitric oxide synthase based on the 6-phenyl-2-aminopyridine structure.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.85 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL40833 | — | — | 1 | 7.40 |
| CHEMBL43678 | — | — | 1 | 7.30 |
| CHEMBL43815 | — | — | 1 | 7.15 |
| CHEMBL43240 | — | — | 1 | 7.15 |
| CHEMBL39186 | — | — | 1 | 7.02 |
| CHEMBL42969 | — | — | 1 | 6.96 |
| CHEMBL42863 | — | — | 1 | 6.95 |
| CHEMBL290476 | — | — | 1 | 6.93 |
| CHEMBL416071 | — | — | 1 | 6.92 |
| CHEMBL39005 | — | — | 1 | 6.92 |
| CHEMBL290875 | — | — | 1 | 6.91 |
| CHEMBL42968 | — | — | 1 | 6.85 |
| CHEMBL40391 | — | — | 1 | 6.85 |
| CHEMBL41343 | — | — | 1 | 6.79 |
| CHEMBL38762 | — | — | 1 | 6.69 |
| CHEMBL43245 | — | — | 1 | 6.66 |
| CHEMBL38845 | — | — | 1 | 6.60 |
| CHEMBL41551 | — | — | 1 | 6.41 |
| CHEMBL247378 | 7-NITROINDAZOLE | — | 1 | 5.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL40833 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL43678 | — | IC50 | = | 50.6 | nM | 7.30 |
| CHEMBL43815 | — | IC50 | = | 70.9 | nM | 7.15 |
| CHEMBL43240 | — | IC50 | = | 70.3 | nM | 7.15 |
| CHEMBL39186 | — | IC50 | = | 96.3 | nM | 7.02 |
| CHEMBL42969 | — | IC50 | = | 109.0 | nM | 6.96 |
| CHEMBL42863 | — | IC50 | = | 112.0 | nM | 6.95 |
| CHEMBL290476 | — | IC50 | = | 117.0 | nM | 6.93 |
| CHEMBL416071 | — | IC50 | = | 121.0 | nM | 6.92 |
| CHEMBL39005 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL290875 | — | IC50 | = | 123.0 | nM | 6.91 |
| CHEMBL42968 | — | IC50 | = | 141.0 | nM | 6.85 |
| CHEMBL40391 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL41343 | — | IC50 | = | 161.0 | nM | 6.79 |
| CHEMBL38762 | — | IC50 | = | 203.0 | nM | 6.69 |
| CHEMBL43245 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL38845 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL41551 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL247378 | 7-NITROINDAZOLE | IC50 | = | 2500.0 | nM | 5.60 |