Assay Detail
Binding
CHEMBL750653
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Inhibition of cloned (from RNA) human Neuronal nitric oxide synthase
22
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
2-Iminopyrrolidines as potent and selective inhibitors of human inducible nitric oxide synthase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 5.33 | 6.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL552935 | — | — | 1 | 6.77 |
| CHEMBL541081 | — | — | 1 | 6.41 |
| CHEMBL227744 | NITROARGININE | 1.0 | 1 | 6.30 |
| CHEMBL553119 | — | — | 1 | 6.07 |
| CHEMBL542710 | — | — | 4 | 5.88 |
| CHEMBL545059 | — | — | 4 | 5.60 |
| CHEMBL545291 | — | — | 1 | 5.52 |
| CHEMBL541090 | — | — | 1 | 5.33 |
| CHEMBL543886 | — | — | 1 | 5.26 |
| CHEMBL552936 | — | — | 2 | 5.08 |
| CHEMBL555587 | — | — | 1 | 5.01 |
| CHEMBL256147 | TILARGININE | 3.0 | 1 | 5.00 |
| CHEMBL553678 | — | — | 2 | 4.92 |
| CHEMBL543888 | — | — | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL552935 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL541081 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL227744 | NITROARGININE | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL553119 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL542710 | — | IC50 | = | 1310.0 | nM | 5.88 |
| CHEMBL545059 | — | IC50 | = | 2530.0 | nM | 5.60 |
| CHEMBL545291 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL542710 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL541090 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL542710 | — | IC50 | = | 5370.0 | nM | 5.27 |
| CHEMBL545059 | — | IC50 | = | 5440.0 | nM | 5.26 |
| CHEMBL543886 | — | IC50 | = | 5460.0 | nM | 5.26 |
| CHEMBL552936 | — | IC50 | = | 8290.0 | nM | 5.08 |
| CHEMBL545059 | — | IC50 | = | 9050.0 | nM | 5.04 |
| CHEMBL555587 | — | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL256147 | TILARGININE | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL552936 | — | IC50 | = | 11200.0 | nM | 4.95 |
| CHEMBL553678 | — | IC50 | = | 12100.0 | nM | 4.92 |
| CHEMBL543888 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL542710 | — | IC50 | = | 20600.0 | nM | 4.69 |
| CHEMBL553678 | — | IC50 | = | 38300.0 | nM | 4.42 |
| CHEMBL545059 | — | IC50 | = | 45700.0 | nM | 4.34 |