Assay Detail
Binding
CHEMBL750654
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against neuronal nitric oxide synthase
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Substituted 2-aminopyridines as inhibitors of nitric oxide synthases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 5.84 | 7.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL40833 | — | — | 1 | 7.12 |
| CHEMBL302657 | — | — | 1 | 7.05 |
| CHEMBL294609 | — | — | 1 | 7.00 |
| CHEMBL293022 | — | — | 1 | 6.47 |
| CHEMBL60372 | — | — | 1 | 6.29 |
| CHEMBL61599 | — | — | 1 | 6.21 |
| CHEMBL299677 | — | — | 1 | 5.92 |
| CHEMBL291544 | — | — | 1 | 5.89 |
| CHEMBL61430 | — | — | 1 | 5.70 |
| CHEMBL59592 | — | — | 1 | 5.66 |
| CHEMBL58492 | — | — | 1 | 5.62 |
| CHEMBL256147 | TILARGININE | 3.0 | 1 | 5.57 |
| CHEMBL61139 | — | — | 1 | 5.48 |
| CHEMBL21619 | 2-AMINOPYRIDINE | — | 1 | 5.32 |
| CHEMBL62083 | — | — | 1 | 5.18 |
| CHEMBL60528 | — | — | 1 | 4.97 |
| CHEMBL59350 | — | — | 1 | 4.96 |
| CHEMBL7889 | L-NIL | — | 1 | 4.74 |
| CHEMBL299906 | — | — | 1 | - |
| CHEMBL292981 | — | — | 1 | - |
| CHEMBL61236 | — | — | 1 | - |
| CHEMBL292690 | — | — | 1 | - |
| CHEMBL294044 | — | — | 1 | - |
| CHEMBL61743 | ISOQUINOLIN-3-AMINE | — | 1 | - |
| CHEMBL225304 | PIMAGEDINE | 2.0 | 1 | - |
| CHEMBL61591 | — | — | 1 | - |
| CHEMBL59925 | — | — | 1 | - |
| CHEMBL61427 | — | — | 1 | - |
| CHEMBL293728 | — | — | 1 | - |
| CHEMBL61990 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL40833 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL302657 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL294609 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL293022 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL60372 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL61599 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL299677 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL291544 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL61430 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL59592 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL58492 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL256147 | TILARGININE | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL61139 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL21619 | 2-AMINOPYRIDINE | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL62083 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL60528 | — | IC50 | = | 10600.0 | nM | 4.97 |
| CHEMBL59350 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL7889 | L-NIL | IC50 | = | 18400.0 | nM | 4.74 |
| CHEMBL299906 | — | IC50 | - | nM | - | |
| CHEMBL292981 | — | IC50 | - | nM | - | |
| CHEMBL61236 | — | IC50 | - | nM | - | |
| CHEMBL292690 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL294044 | — | IC50 | - | nM | - | |
| CHEMBL61743 | ISOQUINOLIN-3-AMINE | IC50 | - | nM | - | |
| CHEMBL225304 | PIMAGEDINE | IC50 | = | 118000.0 | nM | - |
| CHEMBL61591 | — | IC50 | - | nM | - | |
| CHEMBL59925 | — | IC50 | - | nM | - | |
| CHEMBL61427 | — | IC50 | - | nM | - | |
| CHEMBL293728 | — | IC50 | - | nM | - | |
| CHEMBL61990 | — | IC50 | - | nM | - | |
| CHEMBL62077 | — | IC50 | - | nM | - | |
| CHEMBL59235 | — | IC50 | - | nM | - | |
| CHEMBL61939 | — | IC50 | - | nM | - |