Assay Detail
Binding
CHEMBL750671
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Inhibitory activity against N-myristoyltransferase (NMT) of candida albicans
36
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Candida albicans |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Glycylpeptide N-tetradecanoyltransferase (CHEMBL3548) ↗| Type | SINGLE PROTEIN |
| Organism | Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) |
Publication
Conformationally constrained [p-(omega-aminoalkyl)phenacetyl]-L-seryl-L-lysyl dipeptide amides as potent peptidomimetic inhibitors of Candida albicans and human myristoyl-CoA:protein N-myristoyl transferase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 5.98 | 7.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL34342 | — | — | 1 | 7.37 |
| CHEMBL33289 | — | — | 1 | 6.96 |
| CHEMBL33664 | — | — | 1 | 6.96 |
| CHEMBL33525 | — | — | 1 | 6.77 |
| CHEMBL416405 | — | — | 1 | 6.72 |
| CHEMBL540003 | — | — | 1 | 6.57 |
| CHEMBL541030 | — | — | 1 | 6.52 |
| CHEMBL33572 | — | — | 1 | 6.52 |
| CHEMBL33856 | — | — | 1 | 6.47 |
| CHEMBL545169 | — | — | 1 | 6.46 |
| CHEMBL284112 | — | — | 1 | 6.44 |
| CHEMBL285198 | — | — | 1 | 6.28 |
| CHEMBL543282 | — | — | 1 | 6.22 |
| CHEMBL558030 | — | — | 1 | 6.16 |
| CHEMBL33668 | — | — | 1 | 6.12 |
| CHEMBL33714 | — | — | 1 | 6.12 |
| CHEMBL285000 | — | — | 1 | 6.12 |
| CHEMBL286570 | — | — | 1 | 6.11 |
| CHEMBL34801 | — | — | 2 | 5.92 |
| CHEMBL33526 | — | — | 1 | 5.92 |
| CHEMBL33685 | — | — | 1 | 5.89 |
| CHEMBL1790140 | — | — | 1 | 5.41 |
| CHEMBL33342 | — | — | 1 | 5.30 |
| CHEMBL540514 | — | — | 1 | 5.28 |
| CHEMBL34105 | — | — | 1 | 5.17 |
| CHEMBL32539 | — | — | 1 | 5.09 |
| CHEMBL418591 | — | — | 1 | 4.80 |
| CHEMBL285558 | — | — | 1 | 4.80 |
| CHEMBL418409 | — | — | 1 | 4.72 |
| CHEMBL3350017 | — | — | 1 | 4.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL34342 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL33289 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL33664 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL33525 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL416405 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL540003 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL541030 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL33572 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL33856 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL545169 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL284112 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL285198 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL543282 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL558030 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL285000 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL33714 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL33668 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL286570 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL33526 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL34801 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL33685 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL1790140 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL33342 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL540514 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL34105 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL32539 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL285558 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL418591 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL418409 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL3350017 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL416951 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL539106 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL33333 | — | IC50 | = | 365000.0 | nM | - |
| CHEMBL288085 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3350019 | — | IC50 | = | 110000.0 | nM | - |
| CHEMBL34801 | — | IC50 | > | 1000000.0 | nM | - |