Assay Detail
Binding
CHEMBL750676
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Inhibition activity against N-myristoyltransferase (NMT) of candida albicans.
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Candida albicans |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Design and synthesis of novel imidazole-substituted dipeptide amides as potent and selective inhibitors of Candida albicans myristoylCoA:protein N-myristoyltransferase and identification of related tripeptide inhibitors with mechanism-based antifungal activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 6.30 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL291791 | — | — | 1 | 7.70 |
| CHEMBL188653 | — | — | 1 | 7.40 |
| CHEMBL59835 | — | — | 1 | 7.38 |
| CHEMBL6269 | SC-58272 | — | 1 | 7.25 |
| CHEMBL89727 | — | — | 1 | 7.09 |
| CHEMBL291811 | — | — | 1 | 6.89 |
| CHEMBL88093 | — | — | 1 | 6.83 |
| CHEMBL89452 | — | — | 1 | 6.70 |
| CHEMBL62081 | — | — | 1 | 6.51 |
| CHEMBL294596 | — | — | 1 | 6.51 |
| CHEMBL86856 | — | — | 1 | 6.42 |
| CHEMBL313084 | — | — | 1 | 6.07 |
| CHEMBL89801 | — | — | 1 | 5.92 |
| CHEMBL313161 | — | — | 1 | 5.84 |
| CHEMBL299249 | — | — | 1 | 5.81 |
| CHEMBL328767 | — | — | 1 | 5.73 |
| CHEMBL91048 | — | — | 1 | 5.69 |
| CHEMBL88331 | — | — | 1 | 5.52 |
| CHEMBL89017 | — | — | 1 | 5.52 |
| CHEMBL87293 | — | — | 1 | 5.26 |
| CHEMBL314712 | — | — | 1 | 4.21 |
| CHEMBL86687 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL291791 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL188653 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL59835 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL6269 | SC-58272 | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL89727 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL291811 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL88093 | — | IC50 | = | 147.0 | nM | 6.83 |
| CHEMBL89452 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL62081 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL294596 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL86856 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL313084 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL89801 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL313161 | — | IC50 | = | 1450.0 | nM | 5.84 |
| CHEMBL299249 | — | IC50 | = | 1550.0 | nM | 5.81 |
| CHEMBL328767 | — | IC50 | = | 1880.0 | nM | 5.73 |
| CHEMBL91048 | — | IC50 | = | 2050.0 | nM | 5.69 |
| CHEMBL88331 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL89017 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL87293 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL314712 | — | IC50 | = | 62400.0 | nM | 4.21 |
| CHEMBL86687 | — | IC50 | > | 1000000.0 | nM | - |