Assay Detail
Binding
CHEMBL750786
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Compound was evaluated for inhibitory activity against iNOS obtained from RAW 264.7 cells.
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | RAW |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Conformationally constrained NO synthase inhibitors: rigid analogs of L-N-iminoethylornithine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.53 | 5.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL11471 | L-NIO | — | 1 | 5.05 |
| CHEMBL99636 | — | — | 1 | 4.60 |
| CHEMBL317028 | — | — | 1 | 4.60 |
| CHEMBL101713 | — | — | 1 | 4.44 |
| CHEMBL101999 | — | — | 1 | 4.40 |
| CHEMBL319093 | — | — | 1 | 4.33 |
| CHEMBL100183 | — | — | 1 | 4.30 |
| CHEMBL101445 | — | — | 1 | - |
| CHEMBL100505 | — | — | 1 | - |
| CHEMBL102053 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL11471 | L-NIO | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL99636 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL317028 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL101713 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL101999 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL319093 | — | IC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL100183 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL101445 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL100505 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL102053 | — | IC50 | > | 200000.0 | nM | - |