Assay Detail
Binding
CHEMBL750799
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity towards Norepinephrine transporter was determined using NE[3H]Nisoxetine as radioligand
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and ligand binding study of 3 beta-(4'-substituted phenyl)-2 beta-(heterocyclic)tropanes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.04 | 6.61 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL411433 | — | — | 1 | 6.61 |
| CHEMBL117735 | — | — | 1 | 6.30 |
| CHEMBL298580 | — | — | 1 | 6.30 |
| CHEMBL116195 | — | — | 1 | 6.03 |
| CHEMBL14144 | — | — | 1 | 5.53 |
| CHEMBL370805 | COCAINE | 4.0 | 1 | 5.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL411433 | — | IC50 | = | 245.0 | nM | 6.61 |
| CHEMBL117735 | — | IC50 | = | 496.0 | nM | 6.30 |
| CHEMBL298580 | — | IC50 | = | 504.0 | nM | 6.30 |
| CHEMBL116195 | — | IC50 | = | 929.0 | nM | 6.03 |
| CHEMBL14144 | — | IC50 | = | 2960.0 | nM | 5.53 |
| CHEMBL370805 | COCAINE | IC50 | = | 3298.0 | nM | 5.48 |