Assay Detail
Binding
CHEMBL750800
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Binding potency for Norepinephrine transporter using [3H]NE
11
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
3 alpha-(4'-substituted phenyl)tropane-2 beta-carboxylic acid methyl esters: novel ligands with high affinity and selectivity at the dopamine transporter.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.58 | 7.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL14391 | — | — | 2 | 7.44 |
| CHEMBL306208 | — | — | 2 | 7.43 |
| CHEMBL82027 | — | — | 2 | 7.22 |
| CHEMBL2079586 | — | — | 2 | 6.08 |
| CHEMBL1790051 | — | — | 2 | 6.04 |
| CHEMBL370805 | COCAINE | 4.0 | 1 | 5.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL14391 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL306208 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL14391 | — | IC50 | = | 52.4 | nM | 7.28 |
| CHEMBL306208 | — | IC50 | = | 60.1 | nM | 7.22 |
| CHEMBL82027 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL82027 | — | IC50 | = | 275.0 | nM | 6.56 |
| CHEMBL2079586 | — | IC50 | = | 835.0 | nM | 6.08 |
| CHEMBL1790051 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL2079586 | — | IC50 | = | 1230.0 | nM | 5.91 |
| CHEMBL1790051 | — | IC50 | = | 2080.0 | nM | 5.68 |
| CHEMBL370805 | COCAINE | IC50 | = | 3298.0 | nM | 5.48 |