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Assay Detail

CHEMBL750802

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Compound was tested for the ability to inhibit [3H]norepinephrine binding to Norepinephrine transporter in rat synaptosomes
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Tissue Brain
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Norepinephrine transporter (CHEMBL304)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Synthesis and pharmacological evaluation of ring-methylated derivatives of 3,4-(methylenedioxy)amphetamine (MDA).
Parker MA, Marona-Lewicka D, Kurrasch D, Shulgin AT, Nichols DE.
J Med Chem (1998) 41 : 1001 -1005
PubMed 9526575 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 5.71 5.71

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL6391 1 5.71

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL6391 IC50 = 1937.0 nM 5.71