Assay Detail
Binding
CHEMBL750805
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Inhibition of 0.5 nM [3H]nisoxetine binding toNorepinephrine transporter
13
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
3alpha-(4-Substituted phenyl)nortropane-2beta-carboxylic acid methyl esters show selective binding at the norepinephrine transporter.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.26 | 8.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL81525 | — | — | 2 | 8.29 |
| CHEMBL80262 | — | — | 2 | 8.14 |
| CHEMBL80515 | — | — | 2 | 8.01 |
| CHEMBL306208 | — | — | 2 | 7.43 |
| CHEMBL82027 | — | — | 2 | 7.22 |
| CHEMBL2079586 | — | — | 2 | 6.08 |
| CHEMBL370805 | COCAINE | 4.0 | 1 | 5.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL81525 | — | IC50 | = | 5.14 | nM | 8.29 |
| CHEMBL81525 | — | IC50 | = | 5.45 | nM | 8.26 |
| CHEMBL80262 | — | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL80262 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL80515 | — | IC50 | = | 9.8 | nM | 8.01 |
| CHEMBL80515 | — | IC50 | = | 18.8 | nM | 7.73 |
| CHEMBL306208 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL306208 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL82027 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL82027 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL2079586 | — | IC50 | = | 835.0 | nM | 6.08 |
| CHEMBL2079586 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL370805 | COCAINE | IC50 | = | 3300.0 | nM | 5.48 |