Assay Detail
Binding
CHEMBL750807
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Inhibition of norepinephrine transporter (NET) determined using [3H]nisoxetine radioligand.
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis, monoamine transporter binding properties, and behavioral pharmacology of a series of 3beta-(substituted phenyl)-2beta-(3'-substituted isoxazol-5-yl)tropanes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 6.02 | 7.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL317905 | — | — | 1 | 7.36 |
| CHEMBL103523 | — | — | 1 | 7.06 |
| CHEMBL103227 | — | — | 1 | 6.92 |
| CHEMBL316528 | — | — | 1 | 6.74 |
| CHEMBL103228 | — | — | 1 | 6.59 |
| CHEMBL317904 | — | — | 1 | 6.52 |
| CHEMBL316585 | — | — | 1 | 6.40 |
| CHEMBL320627 | — | — | 1 | 6.12 |
| CHEMBL322856 | — | — | 1 | 6.12 |
| CHEMBL1790051 | — | — | 1 | 6.04 |
| CHEMBL329517 | — | — | 1 | 6.04 |
| CHEMBL102279 | — | — | 1 | 6.04 |
| CHEMBL321780 | — | — | 1 | 6.02 |
| CHEMBL322385 | — | — | 1 | 5.77 |
| CHEMBL14144 | — | — | 1 | 5.63 |
| CHEMBL298580 | — | — | 1 | 5.62 |
| CHEMBL322400 | — | — | 1 | 5.60 |
| CHEMBL370805 | COCAINE | 4.0 | 1 | 5.48 |
| CHEMBL317909 | — | — | 1 | 5.48 |
| CHEMBL103223 | — | — | 1 | 5.28 |
| CHEMBL321806 | — | — | 1 | 5.21 |
| CHEMBL100652 | — | — | 1 | 5.20 |
| CHEMBL328415 | — | — | 1 | 5.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL317905 | — | IC50 | = | 43.4 | nM | 7.36 |
| CHEMBL103523 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL103227 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL316528 | — | IC50 | = | 181.0 | nM | 6.74 |
| CHEMBL103228 | — | IC50 | = | 254.0 | nM | 6.59 |
| CHEMBL317904 | — | IC50 | = | 299.0 | nM | 6.52 |
| CHEMBL316585 | — | IC50 | = | 398.0 | nM | 6.40 |
| CHEMBL320627 | — | IC50 | = | 762.0 | nM | 6.12 |
| CHEMBL322856 | — | IC50 | = | 756.0 | nM | 6.12 |
| CHEMBL1790051 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL329517 | — | IC50 | = | 918.0 | nM | 6.04 |
| CHEMBL102279 | — | IC50 | = | 917.0 | nM | 6.04 |
| CHEMBL321780 | — | IC50 | = | 954.0 | nM | 6.02 |
| CHEMBL322385 | — | IC50 | = | 1710.0 | nM | 5.77 |
| CHEMBL14144 | — | IC50 | = | 2340.0 | nM | 5.63 |
| CHEMBL298580 | — | IC50 | = | 2420.0 | nM | 5.62 |
| CHEMBL322400 | — | IC50 | = | 2520.0 | nM | 5.60 |
| CHEMBL370805 | COCAINE | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL317909 | — | IC50 | = | 3330.0 | nM | 5.48 |
| CHEMBL103223 | — | IC50 | = | 5290.0 | nM | 5.28 |
| CHEMBL321806 | — | IC50 | = | 6090.0 | nM | 5.21 |
| CHEMBL100652 | — | IC50 | = | 6320.0 | nM | 5.20 |
| CHEMBL328415 | — | IC50 | = | 6980.0 | nM | 5.16 |