Assay Detail
Binding
CHEMBL750812
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Inhibition of [3H]nisoxetine binding to the norepinephrine transporter in rat midbrain.
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and transporter binding properties of 3 beta-(4'-alkyl-, 4'-alkenyl-, and 4'-alkynylphenyl)nortropane-2 beta-carboxylic acid methyl esters: serotonin transporter selective analogs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 6.38 | 7.83 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL132513 | — | — | 1 | 7.83 |
| CHEMBL442763 | — | — | 1 | 7.66 |
| CHEMBL340447 | — | — | 1 | 7.27 |
| CHEMBL129608 | — | — | 1 | 7.11 |
| CHEMBL131662 | — | — | 1 | 7.08 |
| CHEMBL337507 | — | — | 1 | 7.05 |
| CHEMBL336190 | — | — | 1 | 6.94 |
| CHEMBL340523 | — | — | 1 | 6.91 |
| CHEMBL301281 | — | — | 1 | 6.86 |
| CHEMBL334877 | — | — | 1 | 6.84 |
| CHEMBL132499 | — | — | 1 | 6.83 |
| CHEMBL131354 | — | — | 1 | 6.27 |
| CHEMBL127557 | — | — | 1 | 6.09 |
| CHEMBL128186 | — | — | 1 | 5.88 |
| CHEMBL132329 | — | — | 1 | 5.80 |
| CHEMBL130750 | — | — | 1 | 5.61 |
| CHEMBL335001 | — | — | 1 | 5.55 |
| CHEMBL370805 | COCAINE | 4.0 | 1 | 5.48 |
| CHEMBL129662 | — | — | 1 | 5.41 |
| CHEMBL334546 | — | — | 1 | 5.39 |
| CHEMBL337980 | — | — | 1 | 4.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL132513 | — | IC50 | = | 14.9 | nM | 7.83 |
| CHEMBL442763 | — | IC50 | = | 21.8 | nM | 7.66 |
| CHEMBL340447 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL129608 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL131662 | — | IC50 | = | 83.2 | nM | 7.08 |
| CHEMBL337507 | — | IC50 | = | 89.7 | nM | 7.05 |
| CHEMBL336190 | — | IC50 | = | 116.0 | nM | 6.94 |
| CHEMBL340523 | — | IC50 | = | 122.0 | nM | 6.91 |
| CHEMBL301281 | — | IC50 | = | 139.0 | nM | 6.86 |
| CHEMBL334877 | — | IC50 | = | 144.0 | nM | 6.84 |
| CHEMBL132499 | — | IC50 | = | 147.0 | nM | 6.83 |
| CHEMBL131354 | — | IC50 | = | 532.0 | nM | 6.27 |
| CHEMBL127557 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL128186 | — | IC50 | = | 1330.0 | nM | 5.88 |
| CHEMBL132329 | — | IC50 | = | 1590.0 | nM | 5.80 |
| CHEMBL130750 | — | IC50 | = | 2480.0 | nM | 5.61 |
| CHEMBL335001 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL370805 | COCAINE | IC50 | = | 3298.0 | nM | 5.48 |
| CHEMBL129662 | — | IC50 | = | 3920.0 | nM | 5.41 |
| CHEMBL334546 | — | IC50 | = | 4030.0 | nM | 5.39 |
| CHEMBL337980 | — | IC50 | = | 75000.0 | nM | 4.12 |