Assay Detail
Binding
CHEMBL750840
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Inhibition of [3H]- bremazocine to opioid receptor kappa of guinea pig cerebral membranes was determined
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Effect of modification of the basic residues of dynorphin A-(1-13) amide on kappa opioid receptor selectivity and opioid activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 10.37 | 10.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL266717 | — | — | 1 | 10.70 |
| CHEMBL266515 | — | — | 1 | 10.68 |
| CHEMBL415330 | — | — | 1 | 10.64 |
| CHEMBL438741 | — | — | 1 | 10.62 |
| CHEMBL440446 | — | — | 1 | 10.28 |
| CHEMBL263583 | — | — | 1 | 9.85 |
| CHEMBL263597 | — | — | 1 | 9.82 |
| CHEMBL415617 | — | — | 1 | - |
| CHEMBL440987 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL266717 | — | Ki | = | 0.02 | nM | 10.70 |
| CHEMBL266515 | — | Ki | = | 0.021 | nM | 10.68 |
| CHEMBL415330 | — | Ki | = | 0.023 | nM | 10.64 |
| CHEMBL438741 | — | Ki | = | 0.024 | nM | 10.62 |
| CHEMBL440446 | — | Ki | = | 0.053 | nM | 10.28 |
| CHEMBL263583 | — | Ki | = | 0.14 | nM | 9.85 |
| CHEMBL263597 | — | Ki | = | 0.15 | nM | 9.82 |
| CHEMBL415617 | — | Ki | = | 0.0067 | nM | - |
| CHEMBL440987 | — | Ki | = | 0.0042 | nM | - |